Structural complexity in soft molecular materials and biosciences requires advanced characterization methods that allow tuning of contrast to highlight specific structural details. This workshop will review the state-of-the-art in contrast modulation with neutron and X-ray small angle scattering and assess the potential for synergistic combination of both probes. The workshop will bring together experts in the various techniques of chemical and biological isotope labeling and soft, tender, and hard X-rays. We will use the workshop to explore future research directions in which scientists from these diverse techniques could collaborate and potentially build a more integrated set of tools for the user communities of neutron and synchrotron X-ray user facilities.