7th Workshop on Neutron Scattering Applications in Structural Biology

Spallation Neutron Source

Spallation Neutron Source

Oak Ridge National Laboratory
Flora Meilleur (ORNL)

Oak Ridge National Laboratory, in conjunction with NC State University, present the 7th annual workshop on neutron scattering applications in structural biology. 

Oak Ridge National Laboratory | High Flux Isotope Reactor and Spallation Neutron Source     North Carolina State University

The unique potential of neutron scattering in structural biology arises from the strong interaction of neutrons with hydrogen (H) and its deuterium (D) isotope. This property makes the information available from neutron scattering unique and a valuable complement to data obtained from other structural techniques. Individual hydrogen/deuterium atoms are visualized in neutron density maps from crystallographic data at the resolution typical of most protein structures (2.0 -2.5 Å).Using H/D exchange  and contrast variation, proteins and nucleic acids are sequentially modeled and mapped in large biological complexes using small angle neutron scattering, protein-membrane interactions are revealed using Reflectometry and protein and water dynamics measured using spectroscopy.

The workshop includes a symposium, lectures and tutorials and tours of the High Flux Isotope reactor and Spallation Neutron Source, the world’s leading neutron research facilities.

The workshop is designed for graduate students, post-doctoral researchers and faculty with knowledge of protein function and structure but no or limited experience of neutron sciences.

Subjects include:

  • Crystallography
  • Small Angle Scattering
  • Reflectometry
  • Spectroscopy
  • Imaging
  • Labeling techniques


Course Objectives

  1. Educate participants in neutron scattering techniques, instrumentation and data collection, analysis and interpretation.
  2. Expose participants to cutting-edge research in neutron structural biology.
  3. Build interactions between participants, their university groups, and ORNL neutron scattering experts to develop new research projects.

Course Information

  • 3-minute pitch tall session: A 3-minute pitch talk session will be held on Monday, May 16, 2016. Each participants will presents her/his interest in a concise 3-minute presentation using up to 3 slides. This session will offer participants an excellent opportunity to open the door to further discussions with ORNL neutron scientists. Presentations should be emailed to the workshop organizers no later than Monday, May 2, 2016.

  • Fellowships: Travel and accommodation costs are reimbursed for participants from U.S. institutions. There are no registration fees for any participant. 

  • Application Deadline: Currently open and will end April 1, 2016.


    • 8:00 AM 8:30 AM
      Welcome (Flora Meilleur): Organization details SNS


    • 8:30 AM 9:30 AM
      Deuteration: Kevin Weiss A202 (JINS/8630)



      Oak Ridge National Laboratory
    • 9:30 AM 10:30 AM
      Crystallography I: Dean Myles
    • 10:30 AM 11:00 AM
      Coffee break A202 (JINS/8630)



      Oak Ridge National Laboratory
    • 11:00 AM 12:00 PM
      Crystallography II: Flora Meilleur A202 (JINS/8630)



      Oak Ridge National Laboratory
    • 12:00 PM 1:00 PM
      Lunch SNS Cafeteria

      SNS Cafeteria

      Oak Ridge National Laboratory
    • 1:00 PM 3:30 PM
      HFIR visit (1/2 group) – SNS visit (1/2 group) SNS/HFIR


      Oak Ridge National Laboratory
    • 3:30 PM 4:00 PM
      Coffee break
    • 4:00 PM 5:00 PM
      Participants’ project discussion: Chris Stanley, Flora Meilleur A202 (JINS/8630)



      Oak Ridge National Laboratory